Read more. So, if you are someone who has seen the vials of both types of water, I am sure you can now understand why a bacteriostatic water vial contains considerable volume while a sterile water vial contains just a few milliliters. Bacteriostatic Water for Injection, USP must be made approximately isotonic prior to use. Adverse reactions are rare and can include fever, infection, and thrombosis. We spent 20 hours of research finding optimal recommended dosages for every popular peptide. The action you just performed triggered the security solution. Handlers should adhere to the exact indications or medical instructions. To answer this question, let's look at an example of Dr. Smith, a pharmaceutical scientist who needs to prepare a peptide solution for a clinical trial. It is supplied in a multiple-dose container from which repeated withdrawals may be made to dilute or dissolve drugs for injection. Should I dilute with sterile water (USP grade) or BW? In the 5.161.53.20 This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Our goal is to provide you with the most scientifically accurate, unbiased, and comprehensive information regarding all research peptides and SARMs. In closing, bacteriostatic water is often the preferred choice for injections in a range of contexts. Do not agitate the solution, which can damage the peptides. If I have a 2mg bottle how much water total do I put into the vial? Contact us at info@Bacteriostaticwater.com, Bacteriostatic Water vs. Sterile Water: The Differences That Can Save Your Life. Dr. Fouda uses his extensive knowledge and expertise as a neurosurgeon to medically review articles for accuracy and credibility, ensuring that the information presented is up-to-date and trustworthy. Failure to do so risks the development of hemolysis, damaging the red blood cells [9, 10]. The packaged diluent (Bacteriostatic Water for Injection) contains benzyl alcohol as a preservative. Bacteriostatic water is in many cases the best solvent or dilutant for injections of medications and other therapeutic substances, such as peptides and hormones. New comments cannot be posted and votes cannot be cast. To do the reconstitution of PT-141 you will need: Vial of PT-141 Vial of bacteriostatic water (or sterile water) You must not use this Website if you disagree with any of these Website Standard Terms and Conditions. There may be cases in which sterile water is more appropriate, as outlined above. By displaying Your Content, you grant Buckle LLC a non-exclusive, worldwide irrevocable, sub licensable license to use, reproduce, adapt, publish, translate and distribute it in any and all media. Medically reviewed by Drugs.com. This parenteral preparation is unlikely to pose a threat of fluid overload except possibly in very small infants. Bacteriostatic 0.9% Sodium Chloride Injection, USP is a sterile, nonpyrogenic, isotonic solution of sodium chloride in water for injection. Bacteriostatic Water vs reconstitution solution whats the difference? The following preparation is designed solely for parenteral use only after addition of drugs that require dilution or must be dissolved in an aqueous vehicle prior to injection. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Ob es sich um die Verwaltung von Kundeninvestitionen oder einen umfassenden Plan fr sie zu schaffen und ihre Familie sind unsere zertifizierten Planern gewidmet mit einem auergewhnlichen Service zu bieten. The re-use of sterile water for injections is strictly prohibited. Last updated on Dec 1, 2022. Made with the organic preservative benzyl alcohol, this solution resists contamination to enable multiple doses per vial. If you are already registered, please log in. These Terms will be applied fully and affect to your use of this Website. That being said, using any old water to reconstitute it is a big no-no. It is not intended nor implied to be a substitute for professional medical advice. Bacteriostatic Water for Injection Prescribing Information. Although adverse reactions to intravenous, intramuscular or subcutaneous injection of 0.9% benzyl alcohol are not known to occur in man, experimental studies of small volume parenteral preparations containing 0.9% benzyl alcohol in several species of animals have indicated that an estimated intravenous dose up to 30 mL may be safely given to an adult without toxic effects. It is essential to avoid exposure to light and high temperatures, which can lead to peptide degradation. In a nutshell, in order to make the 1 proper dosage of BPC-157, you would need to draw 10 units of water and then mix it by following the reconstitution guidelines. The universal rule is to use 1 milliliter of bacteriostatic water for every peptide that you reconstitute. Due to the pH, a more apt solution for fluid replacement is normal saline or dextrose. Bacteriostatic Water may be used alone or with other medications. If both items are the same (benzyl alcohol bacteriostatic solutions) why use the different name? Average normal adult daily requirement ranges from two to three liters (1.0 to 1.5 liters each for insensible water loss by perspiration and urine production). Peptides.org makes no claims that any products referenced can cure, treat or prevent any conditions, including any conditions referenced on its website or in print materials. As defined in Section 10.01. RxList does not provide medical advice, diagnosis or treatment. The Bacteriostatic Water can be used in diluting drugs that can subsequently be administered by intravenous, . . It is recognized that there is complex technology associated with the manufacture and control of a lyophilized pharmaceutical dosage form. Bacteriostatic water (BW) has a pH of about 5.7. and our Consult with pharmacist, if available. Air oxidation is yet another threat to the efficacy of the peptide, especially some peptides having amino acids such as free cysteine and tryptophan. 4 people found this helpful. 5.0 out of 5 stars Good product. Unused vials can remain viable for years with proper storage [4]. Prior to buying anything, check that it is compliant where you live with your current government laws. The pH is 5.7 (4.5 to 7.0). 51.222.156.250 Because it is vulnerable to contamination, it is sold in single-dose containers [5]. Each milliliter (mL) contains sodium chloride 9 mg and 0.9% (9 mg/mL) benzyl alcohol added as a bacteriostatic preservative. ], Distributed by Hospira, Inc., Lake Forest, IL 60045 USA. Slowly extract the bacteriostatic water until the solution reaches your desired level. Bacteriostatic Water for Injection, USP is a sterile, nonpyrogenic preparation of water for injection containing 0.9% (9 mg/mL) or 1.1% (11 mg/mL) benzyl alcohol added as a bacteriostatic preservative. Pregnancy: Animal reproduction studies have not been conducted with Bacteriostatic Water for Injection. The struggle is real, people. Package insert / product label publishing any Website material in any other media; selling, sublicensing and/or otherwise commercializing any Website material; publicly performing and/or showing any Website material; using this Website in any way that is or may be damaging to this Website; using this Website in any way that impacts user access to this Website; using this Website contrary to applicable laws and regulations, or in any way may cause harm to the Website, or to any person or business entity; engaging in any data mining, data harvesting, data extracting or any other similar activity in relation to this Website; using this Website to engage in any advertising or marketing. Provisions for sterilizing the inert gas or air supply lines. Reddit and its partners use cookies and similar technologies to provide you with a better experience. AOD 9604 can either be reconstituted in bacteriostatic water (BAC) or sterile water. Due to the bacteriostat, bacteriostatic water comes in a multi-dose formulation for multiple uses. This thread is archived Plus, it is a great dilutant for a range of drugs and therapeutic substances, facilitating aqueous delivery without compromising potency or effectiveness. Bacteriostatic water is very easy to manufacture while sterile water is an arduous process. Reconstitution follows the above method. For more information, please see our The volume of the preparation to be used for diluting or dissolving any drug for injection is dependent on the vehicle concentration, dose and route of administration as recommended by the manufacturer. Dont just shoot the water like a spray or something. Because there is 1ml of bacteriostatic water, this means that we need to mix 5000mcg with 1ml of bacteriostatic water. Buy Bacteriostatic Water from our #1 recommended vendor Disclaimer: Peptides.org contains information about products that are intended for laboratory and research use only, unless otherwise explicitly stated. You will soon see that your peptide powder will be dissolved and the vial will be transparent. Reconstitution means any Securitization Transaction or Whole Loan Transfer. Minors or people below 18 years old are not allowed to use this Website. PT-141 can be reconstituted in bacteriostatic water (BAC) or sterile water. Water distribution depends primarily on the concentration of electrolytes in the body compartments and sodium (Na+) plays a major role in maintaining physiologic equilibrium. Archived post. There are not many side effects associated with using bacteriostatic water. For those of you thinking about the volume of water, 1ml is usually enough for all the peptides available in the market. This information, including any referenced scientific or clinical research, is made available for educational purposes only. Check a preview below or click on the image to see the full document. Remington's Pharmaceutical Sciences, 17th Edition, Mack Publishing Co., Easton, PA, 1985. Its like a chemistry experiment, but instead of blowing things up, youll be improving your health. Storing the peptide in solution form is also a bit risky because they are more prone to degradation. It is used as a solvent or dilutant for drugs or therapeutic compounds that call for aqueous injection. The filling of vials that are to be lyophilized has some problems that are somewhat unique. The recommended dosage of BPC 157 is somewhere between 200mcg to 1000mcg, depending on your body weight. Also, if you are experimenting with new peptides, it is always best to use bacteriostatic water to dilute the peptides. Sterile water is available for injection use such as intravenous, intramuscular and subcutaneous. Most peptide packages contain mixing instruction. Be sure to consult indications for exact dosage and concentration. Obviously, there is a much greater chance of contamination in this type of operation because of the involvement of people. It is always advisable to carefully read them before trying to reconstitute the peptides. Perhaps other adverse effects include fever, abscess formation, thrombosis, tissue death, and infection. Withdraw approximately 1mL of bacteriostatic water from the vial and slowly transfer it into the peptide container. Bacteriostatic water differs from sterile water by the addition of benzyl alcohol as a preservative with a final concentration of 0.9%. However, some of the other dosage forms that are lyophilized, such as hydrocortisone sodium succinate and methylprednisolone sodium succinate have no antibacterial effect when in solution. It is only used for injections such as intravenous, intramuscular and subcutaneous. However, you are not allowed to assign, transfer, or subcontract any of your rights and/or obligations under these Terms. Data are unavailable on the toxicity of other preservatives in this age group. Penetrate the peptide vial as gently as you can. Yes, distilled water can also be used to reconstitute peptides alongside the bacteriostatic and sterile water. Overall, specialists agree that bacteriostatic water for injection is safer and more effective in most cases. Parenteral drug products should be inspected visually for particulate matter Differences Between Bacteriostatic Water vs. Sterile Water Please include what you were doing when this page came up and the Cloudflare Ray ID found at the bottom of this page. In case you experience any of these side effects, you should immediately stop using sterile water for injections and talk to a doctor. Intravenous administration of Bacteriostatic Water for Injection without a solute may result in hemolysis. While most of the peptides will be soluble in bacteriostatic water and sterile water, some really wont, and this will be depending on the polarity of the peptides. These Terms constitute the entire agreement between Buckle LLC and you in relation to your use of this Website, and supersede all prior agreements and understandings. If you dont know what BPC 157 is, it is a peptide that is used by athletes and bodybuilders to recover from injuries and aid in the healing process. Any individual seeking any advice on any prescription medication, or any disease or condition, is advised to refrain from using this site and consult their healthcare provider. did you ever get an answer? Those are bacteriostatic and sterile water. The small volume of fluid provided by Bacteriostatic Water for Injection, USP when used only as a pharmaceutic aid for diluting or dissolving drugs for parenteral injection, is unlikely to exert a significant effect on fluid balance except possibly in very small infants. Muscle + Brawn is independent and reader-supported. Click to reveal Bacteriostatic water should not be used on individuals with benzyl alcohol allergies. Reddit and its partners use cookies and similar technologies to provide you with a better experience. The starter set has all you need to get going, including the following: If you want a little more, check out the premium kit: Qualified handlers are sure to enjoy this top online source for research materials. Bacteriostatic water has a 0.9% benzyl alcohol content and an average pH level of 5.7, while sterile water is free of additives with a pH level of 5.0-7.0. The next step is to do is add the mass of the peptide in mg that you want to reconstitute (This is generally going to be listed on the peptide vial) with the x ml of bacteriostatic water in order to get your desirable dosage in mcg. Bacteriostatic 0.9% Sodium Chloride Injection, USP is a sterile, nonpyrogenic, isotonic solution of sodium chloride in water for injection. However, research is not considered conclusive. pose a threat of fluid overload except possibly in very small infants. There are several actions that could trigger this block including submitting a certain word or phrase, a SQL command or malformed data. Bacteriostatic Water (bacteriostatic water for injection) is a highly purified, sterilized water containing 0.9% benzyl alcohol that is used to dilute or dissolve medications to the appropriate consistency for injection. Muscle + Brawn 2023. Bacteriostatic water is a sterile form of water that has been brought to a pH between 4.5 to 7.0. By rejecting non-essential cookies, Reddit may still use certain cookies to ensure the proper functionality of our platform. Other side effects can include low blood sodium also known as hyponatremia, fluid overload, allergic reactions (tightness in the chest, swelling of the mouth, face, and lips) fever, redness at the site of injection as well as electrolyte imbalance. Certain areas of this Website are restricted from being access by you and Buckle LLC may further restrict access by you to any areas of this Website, at any time, in absolute discretion. [See USP Controlled Room Temperature. Specialists generally consider bacteriostatic water to be a more efficient solvent or dilutant. Reactions which may occur because of this solution, added drugs or the technique of reconstitution or administration include febrile response, local tenderness, abscess, tissue necrosis or infection at the site of injection, venous thrombosis or phlebitis extending from the site of injection and extravasation. (I would personally recommend bacteriostatic water because of its longer shelf-life). Would love your thoughts, please comment. Though their features overlap, bacteriostatic water and sterile water have several significant differences. Privacy Policy. Typical finished product testing that should be reviewed includes dose uniformity testing, sterility testing, and any required stability testing of aged batches of reconstituted solutions. It also is prepared with a bacteriostat, a compound used to prevent any bacterial growth. There have been times when sterile water has been in short supply. Recent inspections have disclosed potency and sterility problems associated with the manufacture and control of lyophilized products. Reactions which may occur because of this solution, added drugs or the technique of reconstitution or administration include febrile response, local tenderness, abscess, tissue necrosis or infection at the site of injection, venous thrombosis or phlebitis extending from the site of injection and extravasation. Consult the manufacturer's instructions for choice of vehicle, appropriate dilution or volume for dissolving the drugs to be injected, including the route and rate of injection. Many people have this mentality that bacteriostatic water and sterile water are the same thing, and that can bring disastrous results. Plus, youll feel like a mad scientist, and who doesnt love that feeling? Follow medical advice and relevant indications for maximum safety and results when using bacteriostatic water for injections. In these Website Standard Terms and Conditions, Your Content shall mean any audio, video text, images or other material you choose to display on this Website. Your access to Peptides.org is subject to our full disclaimer and terms of use. Some of the important aspects of these operations include: the formulation of solutions; filling of vials and validation of the filling operation; sterilization and engineering aspects of the lyophilizer; and testing of the end product. Once you have received the verification code, you will be able to choose a new password for your account. Remove Advertising. Statements regarding products presented on Peptides.org are the opinions of the individuals making them and are not necessarily the same as those of Peptides.org. Other side effects from bacteriostatic water have been reported to include tissue death, venous thrombosis, infection at the injection site, fever, abscess formation as well as a febrile response. I'm diluting my AA (vinegar) to get to 0.6% AA. Each milliliter (mL) contains sodium chloride 9 mg and 0.9% (9 mg/mL) benzyl alcohol added as a bacteriostatic preservative. These are the primary similarities between bacteriostatic water and sterile water [5]: Here are the key differences between bacteriostatic water and sterile water [5]: Despite their similarities, bacteriostatic water and sterile water differ in a few key areas. The volume of the preparation to be used for diluting or dissolving any drug for injection is dependent on the vehicle concentration, dose and route of administration as recommended by the manufacturer. This is the method of peptide reconstitution with bacteriostatic water for injection [13]: Human growth hormone has a range of therapeutic applications, from enhanced physical composition and performance, to treatment of hormone deficiency in adolescents and children [14, 15]. Some drugs for injection may be incompatible in a given vehicle, or when combined in the same vehicle or in a vehicle containing benzyl alcohol. All of our content is written by people with a strong science background, including medical researchers. Water balance is maintained by various regulatory mechanisms. Once you have put the details, our reconstitution calculator will use its algorithm and devise the volume needed to get your peptides reconstituted! The meaning of RECONSTITUTE is to constitute again or anew; especially : to restore to a former condition by adding water. Bacteriostatic Water may cause serious side effects including: Get medical help right away, if you have any of the symptoms listed above. First, lets break down the basics of sterile water. ResearchPeptides.org follows the strictest sourcing guidelines in the health and nootropics industry. Give half a minute for the alcohol to dry so that there is absolutely no risk of bacterial growth. Water for Injection, USP is chemically designated H2O. and ADVERSE REACTIONS. The Buckle LLC is allowed to assign, transfer, and subcontract its rights and/or obligations under these Terms without any notification. It is essential to avoid repeated freeze-thaw cycles and exposure to light and high temperatures. The safety of the plastic has been confirmed by tests in animals according to USP biological standards for plastic containers. Always use as directed on the label. Cloudflare Ray ID: 7c0dd6108cb23fde One would be used to control and record temperatures of the cycle as with sterilizers, and the other would be in the cold spot of the chamber. Buckle LLC, including its officers, directors and employees shall not be held liable for any indirect, consequential or special liability arising out of or in any way related to your use of this Website. Insert your needle tip into the sealed bottle of bacteriostatic water. With our easy-to-use reconstitution calculator, you now dont have to worry about all the multiplication, division or the unit conversion and all. Drop us a comment down below and one of our expert coaches will respond to it, you can also email is at coaching@muscleandbrawn.com. By accepting all cookies, you agree to our use of cookies to deliver and maintain our services and site, improve the quality of Reddit, personalize Reddit content and advertising, and measure the effectiveness of advertising. Both have similar uses and are sterile but have drastically different demographics and indications. Report. (WITHOUT GRABBING YOUR FREE COPY OF THE SARMS AND PEPTIDES SECRETS MINI COURSE). Always double-check which mixture you have because you cannot interchange between these two formulations. This bacteriostat is usually 0.9% benzyl alcohol. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products.
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