Multi-Institutional Assessment of Adverse Health Outcomes Among North American Testicular Cancer Survivors After Modern Cisplatin-Based Chemotherapy. Creating an obituary on Echovita is free. He would undergo five days of treatment, take three weeks off, and then do it all over again. Randomized phase III trial comparing irinotecan/cisplatin with etoposide/cisplatin in patients with previously untreated extensive-stage disease small-cell lung cancer. Results of retroperitoneal lymph node dissection after chemotherapy in patients with pure seminoma in the orchidectomy specimen but elevated serum alpha-fetoprotein. Get service details, leave condolence messages or send flowers in memory of a loved one in Myrtle Beach, South Carolina. Ondansetron: a new antiemetic for patients receiving cisplatin chemotherapy. Prior to Dr. Einhorn's research in the area of platinum combination chemotherapy in patients with metastatic testicular cancer, the survival rate of the disease was approximately 10 percent. Einhorn received a B.S. Extragonadal germ cell tumors: clinical presentation and management. When Donna claims she got her earrings at a mall in Philadelphia, Kelly asks if it was at Franklin Mills, King of Prussia, or . Einhorn, now a distinguished professor and Livestrong Foundation Professor of Oncology at the IU School of Medicine, has driven other major advances in the treatment of testicular cancer, coming up with a more effective and less toxic standard regimen and revealing important principles that are being applied to the treatment of other cancer types. Despite surgery and a round of chemo, his cancer came roaring back, and treatment did nothing but make him sicker. You need evidence of a synergistic effect that can be demonstrated in the lab, as was the case with vinblastine and bleomycin, and later with platinum and other drugs.. Earlier studies gave vinblastine for two years of chemotherapy, even though patients progressed way before the two years were up. Gas cost 53 cents a gallon, pocket calculators made their debut, and most men with testicular cancer died from their disease. An enraged Donna comes to the office to talk to Michael about the whole situation, and the two forgive each other and reconcile by planning a private vacation together. Professor, Department of Radiation Oncology Director, Rubin Center for Cancer Survivorship University of Rochester School of Medicine Rochester, NY. Outcome analysis for patients with elevated serum tumor markers at postchemotherapy retroperitoneal lymph node dissection. Other physician-scientists subsequently built on Dr Einhorns work and developed other platinum compounds. Oh! From stories, to clinical pearls, to basic science and beyond. The average physician might only see patients with the disease in dribs and drabs. TimesMojo is a social question-and-answer website where you can get all the answers to your questions. Along the way came unforgettable experiences, particularly treating John Cleland, the first patient in the world to receive the Einhorn regimen. He even managed to save 20 percent of patients whose disease had spread to the abdomen. 1990;8(4):731-735. 1-20 of 153 1977 . But his father had a heart attack and stopped practicing, closing that door. [1] A pioneer in cancer treatment research, Einhorn developed cisplatin-based chemotherapy regimens that increased cure rates while minimizing toxic side effects.[2][3]. Multimodality treatment of germ cell tumors of the mediastinum. He treated patients with respect, and the respect he got, he earned.. The cancer could have come back, and others might not have responded the same way. Einhorn has directed episodes of Survivor, for which he was nominated for two Emmy Awards. Here we are 40 years later, and platinum is used in first-line chemotherapy for 10 different diseases, he said. Theres a line from a sappy Leonardo DiCaprio movie, The Aviator, says Dr. Einhorn, a Distinguished Professor and the Livestrong Foundation Professor of Oncology. Please accept Echovita's sincere condolences. [4] He was elected to membership in the National Academy of Sciences and American Philosophical Society in 2001. JOHN CLELAND was a 23-year-old newlywed college student when doctors diagnosed him with testicular cancer in November 1973. All Death, Burial, Cemetery & Obituaries results for Larry Einhorn. March 24, 2023 (68 years old) View obituary. Prepare a personalized obituary for someone you loved.. Echovita offers a solidarity program that gives back the funds generated to families. John had failed to be cured with several other forms of chemotherapy and came to me with the idea that we were going to give him platinum, Einhorn recalled. The importance of saying "I love you" during COVID-19, Effective ways of dealing with the grieving process, Solutions to show your sympathy safely during the Covid-19 pandemic. JOHN CLELAND was a 23-year-old newlywed college student when doctors diagnosed him with testicular cancer in November 1973. He became the first Lance Armstrong Foundation Professor of Oncology in 2006. Phase II study of paclitaxel plus gemcitabine salvage chemotherapy for germ cell tumors after progression following high-dose chemotherapy with tandem transplant. He was awarded the Herman B Wells Visionary Award in 2001. Can radiotherapy potentiate the effectiveness of immune checkpoint inhibitors in lung cancer? Fittingly, the children of prominent Indianapolis philanthropists Sidney and Lois Eskenazi recently pledged $300,000 to ensure IU continues Dr. Einhorns tradition and remains a leader in training the next generation of cancer specialists. Urol Oncol. Randall Einhorn is the most frequent director of the series, with 15 credited episodes. Dr. Lawrence Einhorn, famed oncologist and distinguished professor of medicine at Indiana University, visited the UF Department of Medicine this week to discuss how he and his team cured testis cancer. It was fun to be in the presence of greatness, he is so brilliant and down to earth!. He was elected to membership in the National Academy of Sciences and American Philosophical Society in 2002. He became the first Lance Armstrong Foundation Professor of Oncology in 2006. He also dedicated himself to teaching as a way to impact cancer care well beyond Indianapolis, for years serving as the director of the schools hematology and oncology fellowship program. He graduated with a . Primetime Emmy Award for Outstanding Lead Actor in a Comedy Series, https://en.wikipedia.org/w/index.php?title=The_Cover-Up_(The_Office)&oldid=1068068271, This page was last edited on 26 January 2022, at 13:41. Al-Hader AA, Jain A, Al-Nasrallah N, Einhorn LH. Echovita Inc is a registered trademark. Mr. Einhorn had been in prison for nearly 18 years when he died on April 3 in the State Correctional Institution Laurel Highlands in southwestern Pennsylvania. Significant activity of paclitaxel in advanced transitional-cell carcinoma of the urothelium: a phase II trial of the Eastern Cooperative Oncology Group. When using a traditional straight Morse code key, the sender would use one finger to manually hold for the correct dash duration, release, pause for the correct gap duration, tap a dot , release, pause for gap duration, and tap another dot , and release. Doctors ordered a chest x-ray. I do not think Dr Einhorn sleeps until he answers all his e-mails from all who are asking for advice on complicated testicular cancer cases., Hematologist/Oncologist Community Regional Cancer Care Indianapolis, IN, Dr Einhorns research in testicular cancer took patients who were in advanced stages with a poor prognosis and improved their cure rate to over 80%. Young men had already been traveling to then-Indiana University Hospital in the early 1970s because John Donohue, M.D., offered radical surgery that other urologic surgeons would not perform. Pratibha A. Patel. A 25-year single institution experience with surgery for primary mediastinal nonseminomatous germ cell tumors. High-dose chemotherapy for recurrent ovarian germ cell tumors. He was named after Angelas cat, Phillip. A unique and lasting tribute for a loved one. Variants in WFS1 and Other Mendelian Deafness Genes Are Associated with Cisplatin-Associated Ototoxicity. They constitute about 4 percent of the population, and we still do not understand all the late medical and psychosocial sequela of cancer and its treatment, especially as they age. This is the highest success rate of any cancer. Funeral arrangement under the care ofMenorah Chapels at Millburn. Yes, flower arrangements are fulfilled and delivered by local florists from Schaumburg. Cleland and hundreds of thousands of other men around the world are alive today as a result. Fellowship, Indiana University School of Medicine, Indianapolis, IN, Residency, Indiana University School of Medicine, Indianapolis, IN. He inspired a legion of cancer researchers and developed a road map for them to follow. University of Texas MD Anderson Cancer Center, Learn how and when to remove this template message, Experimental and Developmental Therapeutics Program, Indiana University Melvin and Bren Simon Comprehensive Cancer Center, "Indiana University, School of Medicine, Department of Medicine", "Marking a Milestone: Dr. Einhorn discovered testicular cancer cure 40 years ago", "An Interview With Lawrence Einhorn, MD: Testicular CancerDon't Settle for the Status Quo", "How Einhorn Helped Turn a Deadly Cancer Into a Curable Disease", "Lance Armstrong cancer doctor has no mixed feelings", "Yuvraj Singh's disease a model of curable cancer", "Dr. Einhorn Treating Cricketer Yuvraj Singh for Germ Cell Tumor", https://en.wikipedia.org/w/index.php?title=Lawrence_Einhorn&oldid=1114597842, Members of the United States National Academy of Sciences, Articles needing additional references from November 2018, All articles needing additional references, Articles with unsourced statements from November 2018, Creative Commons Attribution-ShareAlike License 3.0, This page was last edited on 7 October 2022, at 09:05. Indiana University, NEW CANCER SURVIVORSHIP RESEARCH PROGRAM BEGINS, Experimental & Developmental Therapeutics, Cancer Drug Discovery & Development Accelerator, Research Program Support for Pilot Projects, Cancer Drug Discovery and Development Accelerator, Community-Academic Collaborative Pilot Research Award, Diversity in Cancer Research Post-Baccalaureate Program, Marking a Milestone: Dr. Einhorn discovered testicular cancer cure 40 years ago, Indiana Institute for Personalized Medicine. The Morse code messages in the cold open are mostly gibberish. Dr. Einhorn and the IU Simon Cancer Center are prepared to advance the future of personalized medicine. High-dose chemotherapy and stemcell rescue for metastatic germ-cell tumors. Moshiri previously established the Lawrence H. Einhorn Chair with a $2 million gift. Id had a chest x-ray in the morning and he sat me down and showed me the chest films, Cleland says, recalling the details as if it were yesterday. As survivors, trainees, colleagues and friends celebrated the milestone, Dr. Einhorn seized the opportunity to announce his latest focus: a new research program that seeks to spare survivors from the burden of the cure long-term, sometimes life-threatening side effects of chemotherapy. from Indiana University in 1965 and his M.D. The ending credits open with In Memory of Larry Einhorn; Larry Einhorn was the recently deceased father of Randall Einhorn who directed several episodes of the series. He served his internship and residency at IU Medical Center, followed by a fellowship in Hematology/Oncology at the M.D. He served his internship and residency at IU Medical Center, followed by a fellowship in Hematology/Oncology in 1971-72. Einhorn received a B.S. He was the schools first medical oncologist, and his expertise in cancer drug therapy complemented Dr. Donohues surgical proficiency. So, it will be the ultimate romantic moment when both of you love birds are staring at each others eyes and you say those three words just by blinking. His research helped make the treatments of testicular cancer a gold standard for how we treat cancer today., REGN5459 Delivers Dose-Dependent Responses in Relapsed/Refractory Myeloma, Camidge and Jalal on Setting up an Infrastructure for Success in Life and Work, Gifts from Walther, Regenstrief Foundations Create Cancer Informatics Chair at IU Simon Comprehensive Cancer Center, $8 million gift establishes research fund, endowed position for bile duct cancer at IU, IU School of Medicine Researchers Publish Findings Which Could Help Prevent Side Effects for Breast Cancer Patients, IU School of Medicine Names First Walther Scholar in Psycho-Oncology, Dr Daneschmand on Data From SunRISe-1 With TAR-200 and Cetrelimab in BCG-Unresponsive NMIBC, Dr Saad on PSA Response and Time to PSA Progression With Abiraterone Acetate and Olaparib in mCRPC, Pembrolizumab Monotherapy Demonstrates Clinical Efficacy in High-risk NMIBC, TAR-200 Produces High CR Rates, Tolerability in BCG-unresponsive NMIBC, OncLive National Fellows Forum: Lung Cancer 2023, Join us in Chicago for Giants of Cancer Care, Leading Genome Researchers Confident That the Cancer Puzzle Will Be Solved, Targeted Therapy Challenges:More Cancer Genes Discovered, Mutational Burdens Defined, RAS Mutations Ready for Prime Time in mCRC, Promising Biomarkers Emerging Across the Spectrum of Prostate Cancer Care, USPSTF, ASCO Issue More Guidance on Genetic Testing Based on Family History, Novel Imaging Techniques for Metastatic Prostate Cancer Advance, Radium 223 Option Hinges on Bony Disease Burden in mCRPC, Nab-Paclitaxel Explored as Adjuvant Therapy in Pancreatic Cancer, Expanded Molecular Test Registry and Upgraded Data Systems Needed, Making Progress in Treating Relapse in Childhood Leukemia, Patients With Advanced Cancer Benefit When Palliative Care Starts Earlier, How Einhorn Helped Turn a Deadly Cancer Into a Curable Disease, New Model for Outpatient Induction Chemotherapy for AML and MDS Explored, HPV Test With Genotyping Tops Cervical Cancer Screening Strategies. His legacy will forever be linked with revolutionizing testicular cancer treatment. Nephrology, Hypertension & Renal Transplantation, Pulmonary, Critical Care, and Sleep Medicine, 2019 Celebration of Research photo gallery, Learning from the Famed Oncologist Dr. Larry Einhorn, In recognition of World Kidney Day, UF Health physician answers questions about kidney disease, This page uses Google Analytics (Google Privacy Policy). Antiemetic therapy for multiple-day chemotherapy and additional topics consisting of rescue antiemetics and high-dose chemotherapy with stem cell transplant: review and consensus statement. Christine May Ochs Einhorn, age 95May 1, 1923 - January 24, 2019 Christine May Ochs Einhorn, 95, of Newton, died at 515 p.m. on Thursday, January 24, 2019 at the Newton Care Center. Phase III study of cisplatin, etoposide, and concurrent chest radiation with or without consolidation docetaxel in patients with inoperable stage III non-small-cell lung cancer: the Hoosier Oncology Group and U.S. Oncology. He was a good role model, Einhorn said. J Clin Oncol. Cast members Steve Carell and Paul Lieberstein also directed episodes this season, though they had previously directed for the series. We simply need to replace every dot with the sound di and every dash with the sound dah.. Worried, Michael hires Dwight Schrute (Rainn Wilson) to tail her to see if she spends time with anyone else. Trivia. "[5] James Poniewozik of Time gave the episode a positive review writing "Credit to the show for setting that up (Michael realizing he is a mistress), though it eluded me and, I suppose, everyone else not versed in the secret signals of heart-shaped jewelry.[6]. Browse Richmond local obituaries on Legacy.com. Cisplatin was found to be too toxic, causing severe vomiting, neuropathy, hearing loss and kidney damage in these patients, and it failed to stop the growth and spread of most of the cancers. List of episodes. After earning a BS from IU, Einhorn attended medical school at the University of Iowa. Improved chemotherapy in disseminated testicular cancer. It was there that he met his future wife, Claudette Phillips, when his roommate set them up on a date. A few years later, he was invited to present his results at the annual meeting of the American Society of Clinical Oncology, the worlds premier organization of cancer specialists. Moore AM, Einhorn LH, Estes D, et al. Dr. Einhorn had cured testis cancer. I love teaching and dealing with brilliant minds, lighting a spark in them to make a difference in their field. IU. Although the combination was useful, Einhorn was looking for something still more effective when, in 1974, he learned of a phase I trial of single-agent cisplatin that had sparked brief remissions in patients with testicular cancer who had previously been treated with chemotherapy. Metastatic malignant transformation of teratoma to primitive neuroectodermal tumor (PNET): results with PNET-based chemotherapy [published online June 24, 2013]. When he told me, it was like I was floating in the air. One of the rst things that I wanted to do when I joined the fellowship program at Indiana University was to introduce myself to Dr Einhorn because he is a nationally and internationally recognized authority in oncology. 1981;41(9 Pt 1):3275-3280. But many of the patients he operated on still developed a recurrence. In fact, researchers with theIndiana Institute for Personalized Medicine-- led by David Flockart, M.D., PhD. At the time, cisplatin was being used in cancers with no standard therapies, after patients had failed other regimens; however, it caused nausea, vomiting, numbness and tingling in the legs, kidney problems, and ringing in the ears before it could do much to fight disease. I know I was touching the mattress, but it sure never felt like it. In fact, Cleland felt downright awful. While in the first year of his fellowship, a third-year fellow named Jeffrey Gotleib developed testis cancer and died from it. from the University of Iowa in 1968. To schedule an appointment with a faculty member physician of IU School of Medicine, contact Indiana University Health at 888-484-3258 or use the physician finder by clicking the button below. He receives hundreds of e-mails daily from patients with testicular cancer, their family members, providers, and fellow oncologists, from the United States and abroad. Einhorn LH, Brames MJ, Juliar B, Williams SD. 2022 Resident of Richmond, CA Larry . Directed by Rainn Wilson (Dwight Schrute). Dr. Donohue died in 2008, but his legacy and Dr. Einhorns achievements endure. He spends two and a half days each week seeing patients who have testicular cancer, lung cancer, and a smattering of rare diseases that dont fit into any organ type, like cancer primary site unknown., He splits his remaining time between lecturing and attending conferences; designing and running clinical trials; and teaching interns, residents, and fellows. The Giants of Cancer Care awards program, which the Intellisphere Oncology Specialty Group launched last year, honors oncology specialists whose work has made a significant impact on the lives of patients with cancer. I hope my legacy lives on through others doing their chosen work.. He and Claudette have two grown children and a 7-year-old granddaughter, Georgia. Although Einhorn describes his work as a cruel mistress that doesnt leave him much time for hobbies like reading crime novels, playing tennis, and attending sporting events, he enjoys what he does, especially in light of a simple lesson it has taught him. Its used more widely in more diseases than any single cancer drug, yet it almost never made it out of the gate. Einhorns trifecta with the regimen is a reminder, he said, that other landmark treatments may be waiting in the wings as investigators research new drugs, such as molecularly targeted agents, to treat cancer. . Phase II study of cisplatin plus epirubicin salvage chemotherapy in refractory germ cell tumors. J Urol. Einhorn LH, Nagy C, Werner K, Finn AL. Cancer Res. The "growing teratoma syndrome" in primary mediastinal nonseminomatous germ cell tumors: criteria based on current practice. One of the fresh-faced doctors he helped mold was Dr. Loehrer, now the director of the IU Simon Cancer Center. The episode was written by Lee Eisenberg and Gene Stupnitsky, their third writing credit of the season after "The Lover" and "Scott's Tots." I think oncologists recognize that more than others. With unsurpassed leadership in testis cancer treatment, Indiana University is well-poised to develop a program of significant magnitude for all cancer survivors. The Cancer Survivorship Research Program will benefit testis cancer patients as well as five million more people who are treated with Cisplatin each year for 12 different types of cancer. A unique and lasting tribute for a loved one. Management of stage I testicular germ cell tumours. He was 79. When Michael confronts Donna about this, she reveals that her relationship with Michael is actually an extramarital affair. Dr. Einhorn has also been involved in the clinical development of new drug therapies. Anderson Hospital Tumor Institute in Houston, Texas. Despite 40 years of celebrity in his field, friends and family note that Larry, as hes known, remains the same modest, thoughtful person he was before he developed the cure. Larry Einhorn: The Breakthrough, The Cure, The Vision, The Legacy, The Teacher. As a result, the platinating agents are now one of the most commonly used group of cytotoxic drugs worldwide. 189 Gill Ln, Iselin, NJ 08830. Graveside services were held Friday, June 29, 2018 in the Golden Hill Cemetery, Lakewood, Colorado. How do you say I love you too in Morse code? Relatives and friends are invited to attend the funeral on Friday, Dec. 22, at 9 a.m. at the Krowicki McCracken Funeral Home, 2124 E. St . Phase II study of paclitaxel plus gemcitabine salvage chemotherapy for germ cell tumors after progression following high-dose chemotherapy with tandem transplant. His service completed, Einhorn returned to IU and his mentor, Robert J. Rohn, MD, who had inspired him to treat patients with cancer. I wish that we had a drug like platinum in the other diseases I treat, he said, but at least it shows you what is possible, and underscores the urgency of doing clinical trials, because if were not looking at new drugs and new studies in other cancers, were always going to be at the status quo.. In the episode, Michael suspects Donna is cheating on him, and he pays Dwight $50 plus expenses to investigate. Dr. Einhorn turned 72 in September, but dont bother asking about retirement. Donna ends up meeting Michael and starting a relationship with him over the course of a few episodes. She is from the same farming community as Dwight and is his third cousin (which is great for bloodlines and technically not incest), works as a brussel sprout farmer, and weaves colourful and durable blankets and rugs. With all this in mind, Dr. Einhorn offered John Cleland this brand new therapy. Dr. Einhorn pioneered the development of the life-saving medical treatment in 1974 for testicular cancer, increasing the survival rate from 10% to 95% (Einhorn & Williams 1980). Later on, their relationship begins to weaken after Michael suspects that she is cheating on him. Summary report 7th Annual Targeted Therapies of the Treatment of Lung Cancer. Still another was Charles Blanke, MD, who chairs SWOG, one of the largest cancer research cooperatives in the world, and who is responsible for some of the seminal research involving the drug Gleevec. 2007;357(4):340-348. Even back then I felt medicine was a noble profession.. -- work to bridge the gap between genomics research and patient care. Donohue and Einhorns foresight and commitment to research. Post chemotherapy RPLND in patients with elevated markers: current concepts and clinical outcome. During Dwights competition with the computer, he sends the computer an insult in binary, saying Why dont you 0111111011011. Utilization of sperm banking and barriers to its use in testicular cancer patients. J Clin Oncol. At the same time, they are continuing to study psychosocial aspects of testicular cancer. Visiting will take place on Thursday from 4 to 8 p.m. At the same time, he has helped develop new treatment strategies for small cell lung cancer. His father was a family practitioner with an office attached to the family home. He was born and raised in Ohio, the United States. 2007;25(5):513-516. Marvin Einhorn, 83, beloved husband and friend of Minna for 67 years. Einhorn had the privilege of selecting the first Eskenazi fellow, Jill Kremer, MD. Lung Cancer. Who directed the office? But that is only part of his legacy. He is a loyal fan of IU basketball and the Indianapolis Colts. "He helped turn metastatic testicular cancer, a nearly always fatal malignancy, into a curable entity, harnessing the power of combination, platinum . The Livestrong Foundation, which he set up by himself with his own funds, blood, sweat, and tears, has done a remarkable job of helping the cancer community. In all his years at IU, Einhorn has never been tempted to leave. It might have been permanently shelved, but Dr. Einhorn noticed that the drug was killing cancer cells in a very small subset of patients with testis cancer. He has been a long-standing member of the Multi-National Association for Supportive Care in Cancer (MASCC). 1994;12(11):2264-2270. The study made the Einhorn regimen a historical footnote, he recalled, because we showed we had fewer side effects with etoposide and a higher cure rate., Then, an investigation considered shortening the duration of the new standard therapy. March 23, 2023 (59 years old) View obituary. Einhorns goal upon arriving at IU was to study cancers that were already somewhat responsive to chemotherapy, so that small changes in treatment might lead to big improvements in outcome. He probably still has it, she quips. Even someone whod never looked at chest films before would probably know that this guy was in serious trouble. My favorite is when he is the horse and she is the rider and hes down on his hands and knees, whinnying and riding around with her on his back. It was directed by Rainn Wilson, who also portrays Dwight Schrute on the show, marking his television directorial debut.[1]. Why oncologists should support single-payer national health insurance. But Dr. Einhorn was intrigued by the disease regression experienced by a very small number of testis cancer patients in the trial and developed a strategy to combine Cisplatin with two additional drugs that also were effective in killing testis cancer cells. Would you like to offer Harry Michael Einhorns loved ones a condolence message? Fortuitously, another door opened. And then, of course, he gets up and his back hurts him, but he would never refuse to let her do it. He was just shy of his 31st birthday. We gave patients three courses of bleomycin plus etoposide plus platinum over 9 weeks versus four courses over 12 weeks, with the same cure rate, Einhorn said. He pays Creed Bratton (Creed Bratton) to threaten him, and further convinces Andy that the conspirators intend to kill him. In fact, the very thought of coming to the hospital would cause anticipatory vomiting. By adding a single agent to a fledgling treatment regimen, Lawrence H. Einhorn, MD, transformed testicular cancer from a methodical killer of young men into a highly curable condition for many patients, including famed cyclist Lance Armstrong, whom Einhorn treated. Randall Einhorn Trivia (5) The ending credits open with "In Memory of Larry Einhorn"; Larry Einhorn was the recently deceased father of Randall Einhorn who directed several episodes of the series. When he found out Donna had slept with Ricky, Gareth figured she was promiscuous and tried to get her attention, only to be angrily shot down. His cancer seemingly melted away, and it did not return. Though Darryl intends to use the video to further embarrass Andy, the printer indeed catches fire and explodes. Dr. Einhorn's clinical interests include solid tumor oncology, specifically within the fields of genitourinary and lung cancers. I knew just from their body language and body motions that somebody had some good news or something was happening that was pretty happy, he says.
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